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    Yes they can.

    And it’s enforceable literally at the business end of a firearm.

    SCOTUS - 197 U.S. 11 (1905) - Jacobson v Massachusetts

    This 7-2 decision in 1905 has been referenced and upheld more than once….. Two examples are Zucht v. King (1922) mandatory vaccinations in order to go to school ….and…. Vernonia School District 47J v. Acton, 515 U.S. 646 (1995) mandatory random drug testing of students at school.